THE EFFECT OF BISPHOSPHONATE RISEDRONATE HYDROGEL ON ALKALINE PHOSPHATASE AND OSTEOCLASTS DURING RELAPSE MOVEMENT

Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement
 Materials methods: The research design is experimental with time series. lower incisors 75 guinea pigs are distally moved using open coil spring. were divided into three groups: without (group A; n = 25); given 250 µmol/L B; 25), 500 C; 25). Risedronate applied intrasulcularly in mesial part gingival sulcus every 3 days. After 14 days stabilization, spring was removed (bisphosphonate administration continued). relapsed teeth ALP levels 0, 3, 7, 14, 21 measured. measured by hematoxylin eosin staining. ANOVA test used to determine difference groups their interactions concentration time. 
 Results: There a significant day (p 0.019, p